Insights in dynamic kinome reprogramming as a …
Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML
Glycogen synthase kinase 3 in MLL leukaemia maintenance …
Glycogen synthase kinase 3 (GSK3) is a multifunctional serine/threonine kinase that participates in numerous signalling pathways involved in diverse physiological processes. Several of these pathways are implicated in disease pathogenesis, which has prompted efforts to develop GSK3-specific inhibitors for therapeutic applications.
Pharmacologic Inhibition of the Menin-MLL Interaction …
Borkin et al. develop highly potent and orally bioavailable small molecules that block the interaction between menin and MLL. These compounds inhibit the growth of model and patient-derived leukemia cells that express MLL-fusion proteins in vitro and prolong the survival of mice bearing MLL leukemia.
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Convert milliliters to fluid ounces (mL to fl oz) with the volume conversion calculator, and learn the milliliter to fluid ounce formula.
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Inhibition of BET recruitment to chromatin as an effective …
These data provided the basis for therapeutic intervention in MLL-fusion leukaemia, via the displacement of the BET family of proteins from chromatin. We show that a novel small molecule inhibitor of the BET family, GSK1210151A (I-BET151), has profound efficacy against human and murine MLL-fusion leukaemic cell lines, through the …
In vivo eradication of MLL/ENL leukemia cells by NK cells in …
In this study, to clarify how the presence of immune cells affects leukemia development, MLL/ENL-HPCs were transferred into immune-competent or immune-deficient mice without any preconditioning ...
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DOT1L O-GlcNAcylation promotes its protein stability and MLL …
DOT1L is a versatile histone H3K79 methyltransferase with a prominent role in MLL-fusion leukemia, yet little is known about how DOT1L responds to extracellular stimuli. Here, we report that DOT1L protein stability is regulated by the extracellular glucose level through the hexosamine biosynthetic pathway (HBP).
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Rearrangement of the MLL Gene in Acute Lymphoblastic …
Translocations involving chromosome band 11q23 are very frequent in both acute lymphoblastic and acute myeloid leukemias and are the most common genetic alteration in infants with leukemia. In all ...
Malignant hematopoietic cell lines: in vitro models for the …
Leukemia–lymphoma cell lines have been instrumental in the cytogenetic and molecular analysis of recurring chromosome rearrangements, notably translocations and inversions, thus illuminating the ...
Cell of origin determines clinically relevant subtypes of MLL …
Experiments with mouse models demonstrated MLL -rearranged AML ( MLL -AML) may arise from hematopoietic stem and myeloid progenitor cells, 10, 11 making the leukemia cell of origin a possible ...
The molecular biology of mixed lineage leukemia
The molecular biology of mixed lineage leukemia. Mixed-lineage-leukemia is an aggressive leukemia that predominantly occurs in pediatric patients and is characterized by the expression of fusion genes involving the histone methyltransferase MLL and a variety of fusion partners. It is now clear that MLL fusion partners can activate transcription ...
Millilitres to Ounces (ml to oz) conversion
Milliliters to Ounces (mL to oz) conversion calculator for Volume conversions with additional tables and formulas.
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Mixed Lineage Leukemia (MLL)
Mixed lineage leukemia is characterized by chromosomal translocations of the mixed lineage leukemia (MLL) gene to form fusion proteins with partner proteins. Many of these MLL-fusion partners belong to the super-elongation complex involved in regulating transcriptional elongation. MLL-fusions can create oncogenic transcription factors that ...
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent …
MLL, involved in many chromosomal translocations associated with acute myeloid and lymphoid leukemia, has >50 known partner genes with which it is able to form in-frame fusions. Characterizing important downstream target genes of MLL and of MLL ...
MLL -Rearranged Acute Lymphoblastic Leukemia
The MLL -r-ALL is characterized by an extensive promoter hypermethylation and silencing of tumor suppressor genes leading to a higher relapse risk [ 69, 70 ]. Hypomethylating agents have the ability to reverse aberrant DNA methylation and induce apoptosis in leukemia cells.
Stabilizing the Mixed Lineage Leukemia Protein
The translocation of the gene encoding mixed lineage leukemia with other genes results in chimeric, oncogenic proteins. A recent study shows that stabilization of wild-type MLL (encoded by the untr...
Structural basis of nucleosome recognition and modification by
Cryo-electron microscopy structures of mixed-lineage leukaemia methyltransferases 1 and 3 associated with unmodified or mono-ubiquitinated nucleosome reveal the structural basis for the activity ...
Molecular Basis of the Mixed Lineage Leukemia …
Chromosomal translocations targeting the mixed lineage leukemia (MLL) gene result in MLL fusion proteins that are found in aggressive human acute leukemias. Disruption of MLL by such translocations leads to …
HOXA9 is required for survival in human MLL-rearranged …
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biologic characteristics and often have an unfavorable prognosis. Gene expression analyses demonstrate a distinct profile for MLL-rearranged leukemias with consistent high-level expression of select H …
Convert ml to oz
How many ml in 1 oz? The answer is 29.5735296875. We assume you are converting between milliliter and ounce [US, liquid] . You can view more details on each …
The MLL recombinome of acute leukemias in 2013
Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients.
The RNA-binding protein IGF2BP3 is critical for MLL-AF4 …
Here, we find that the RNA-binding protein IGF2BP3, which is overexpressed in MLL-translocated leukemia, strongly amplifies MLL-Af4-mediated leukemogenesis. Deletion of Igf2bp3 significantly increases the survival of mice with MLL-Af4-driven leukemia and greatly attenuates disease, with a minimal impact on baseline hematopoiesis.
The Pathogenesis of Mixed Lineage Leukemia
Aggressive leukemias arise in both children and adults as a result of rearrangements to the Mixed Lineage Leukemia (MLL) gene located on chromosome 11q23. The MLL gene encodes a large histone methyltransferase that directly binds and positively regulates ...
Rearrangement of the MLL gene confers a poor prognosis in
MLL gene rearrangements are associated with an extremely poor prognosis in infants with acute lymphoblastic leukemia (ALL), but little is known about their clinical significance in older children. Therefore, we studied 45 cases of childhood ALL with abnormalities of chromosome 11q23 for rearrangemen …
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